Bone marrow chimaeric mice. Mice that receive bone marrow transfer following lethal irradiation to repopulate the haematopoietic stem cell population (which gives rise to thymocytes) with cells of a ...
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA). We investigated ...
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