Regional responses to inhaled toxicants are essential to understand the pathogenesis of lung disease under exposure to air pollution. We evaluate the effect of combined allergen sensitization and ...

DOI: 10.1038/s42004-025-01526-x A team led by scientists at the University of Nottingham's School of Pharmacy demonstrated a new cryogenic mass spectrometry approach for depth profiling frozen tiny ...

Mass spectrometry is a cornerstone technique across various scientific disciplines, enabling precise analysis of complex samples, characterization of atom clusters and molecules, and elucidation of ...

A research team led by scientists from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences, in collaboration with partners, has developed a novel high-spatial-resolution ...

Understanding how fat molecules are distributed and function in living organisms is key to uncovering mechanisms of aging, disease, and metabolism. Caenorhabditis elegans, a transparent roundworm, is ...

Researchers and R&D scientists are often sitting on a gold mine of older experiment data, with no good way to extract ...

Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) is a powerful analytical technique that enables spatially resolved molecular analysis of biological tissues. It ...

A new microfluidic method preserves worm anatomy to link lipid signals with body structure using mass spectrometry imaging. Understanding how fat molecules are distributed and function in living ...

In a recent study published in the journal Nature Metabolism, a team of researchers conducted detailed longitudinal profiling and analysis of the lipidome using plasma samples from over a hundred ...

For biologists, seeing is believing. But sometimes biologists have a hard time seeing. One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of ...

Ten consecutive tissue sections from a single C. elegans nematode, shown as optical images (left stack) and corresponding lipid distribution maps generated by MALDI mass spectrometry imaging (MSI) ...