Similar to the way DNA damage can contribute to human diseases such as cancer, it can also disrupt growth, development and ...

Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 ...

DNA polymerase theta (Pol θ) orchestrates a distinct, error-prone route of double-strand break (DSB) repair known as microhomology-mediated end joining (MMEJ) or theta-mediated end joining (TMEJ).

Salk Institute scientists identify YAF9B as a protein activated by DNA damage, acting like an emergency responder to ...

Researchers have captured the first atomic structures of human SMUG1, an enzyme that helps cells repair damaged DNA. The ...

"The DNA inside our cells is constantly experiencing damage, and DNA repair is happening all the time to fix that damage and keep our cells healthy. Now, however, it seems these repair processes can ...

DNA polymerases are central to the faithful duplication and maintenance of the genome. Beyond replication, specialised polymerases are recruited to distinct repair pathways to restore integrity after ...

Scientists have uncovered a critical role for rapid DNA repair in maintaining genome stability. A new study reveals that repair of double-strand breaks (DSBs) in nuclear DNA in plants serves as a ...

Outcomes of nephrectomy in patients with pathologic complete response to immune checkpoint inhibitor therapy for renal cell carcinoma: A multicenter study. Sarcomatoid versus rhabdoid ...

A new study suggests melatonin supplements may help night shift workers boost their body's DNA repair processes, potentially offsetting some of the damage linked to working overnight. The findings are ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...