If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

DNA replication in eukaryotic cells is a highly coordinated, multi-step process that ensures precise duplication of the genome prior to cell division. In late mitosis and early G1 phase, the Origin ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

Every human cell packs roughly two meters of DNA into a nucleus only six micrometers wide. That ratio, confirmed by ...

DNA replication is the process by which a cell makes an identical copy of its DNA. This process is performed at the beginning of every cell division so that when the cell divides, each daughter cell ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...

Researchers at Oregon Health & Science University have identified a previously unrecognised role for the cancer-associated ...

The Polymerase Chain Reaction (PCR) is a technique for the amplification of DNA in vitro (this describes experiments with cells outside their normal environment). PCR amplifies DNA using complementary ...

Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell division—a discovery that could lead to new cancer therapies, according to ...

Eukaryotic chromosomes replicate from multiple discrete loci termed origins of replication. These sites are first recognised by the origin recognition complex (ORC), which, together with Cdc6 and Cdt1 ...